Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 51, Issue 12, Pages 2834-2848Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201106628
Keywords
carboxylic acids; cyclosporine; glycosylation; isonitriles; multicomponent coupling
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Funding
- National Institutes of Health [CA103823, CA28824, 1F32CA142002-01A1, K99GM097095-01]
- American Cancer Society [PF-11-014-01-CDD]
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We describe herein our recent explorations in the field of isonitrile chemistry. An array of broadly useful coupling methodologies has been developed for the formation of peptidyl and glycopeptidyl amide bonds. We further describe the application of these methods to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles.
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