Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 349, Issue 4-5, Pages 535-538Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200600558
Keywords
automation; debenzylation; deprotection; flow hydrogenation; palladium; peptides
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A versatile, fully automated flow hydrogenator has been developed that is able to perform sequential flow optimisation experiments, flow library hydrogenation, or iterative scale-up hydrogenation. ne behaviour of a palladium catalyst in effecting removal of O-benzyl and N-benzyloxycarbonyl protecting groups has been investigated. Significant observations relating to maintaining optimal throughput are reported. A small library of peptidic derivatives has been deprotected in high yield and purity.
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