Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 3, Pages 428-431Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0604984
Keywords
-
Funding
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [N01 CO 12400] Funding Source: Medline
Ask authors/readers for more resources
Two new chondropsin-type macrolide lactams, poecillastrins B (1) and C (2), were isolated from aqueous extracts of the marine sponge Poecillastra sp. These trace metabolites were isolated in low yield (400-600 mu g), and their structures were determined primarily by analysis of NMR data acquired using a cyrogenically cooled probe. High-quality 1D and 2D NMR data sets allowed complete assignment of the spectroscopic data and defined the new structures as 35-membered ring analogues of poecillastrin A (3). Compounds 1 and 2 showed potent cytotoxic activity against a human melanoma tumor cell line (LOX) with an IC50 value of less than 1 mu g/mL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available