Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 100, Issue 4, Pages 883-896Publisher
WILEY
DOI: 10.1002/jcb.21091
Keywords
p53; DNA damage response; DNA repair; pro-survival; cell cycle
Categories
Ask authors/readers for more resources
The tumor Suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell Survival by inducing cell cycle arrest, DNA repair, and other pro-survival pathways. However, when cells accumulate DNA damage or demonstrate aberrant growth, p53 can direct the elimination of damaged cells. In this review, we will discuss the transcriptional-dependent and -independent roles of p53 in regulating the DNA damage response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available