Journal
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
Volume 27, Issue 2, Pages 168-173Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1475-1313.2006.00449.x
Keywords
contact lenses; corneal staining; multipurpose solutions; polyhexamethylene biguanide; polyquad; silicone hydrogels
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Purpose: To compare the clinical performance of a new polyhexamethylene-biguanide (PHMB)- vs a polyquad-based contact lens care regime with two silicone hydrogel contact lenses. Methods: This study was a randomised, controlled and investigator-masked (to the lens regimen) clinical study where the clinical performance of two multipurpose contact lens solutions was compared at a single site. Forty-one existing contact lens wearers were recruited and fitted randomly with either galyfilcon A or lotrafilcon A contact lenses. Subjects wore the same lens type for a period of 2 months but used a different care regime (PHMB- and polyquad-based) in a crossover manner, each for a period of 1 month. The primary outcome measure was the difference in corneal staining. Corneal staining was graded in five different locations: central, superior, inferior, temporal and nasal. Measurements of conjunctival redness, limbal redness, conjunctival staining and papillary conjunctivitis were also carried out throughout the study. Biomicroscopic measures were graded using the Efron grading scales. A variety of symptoms were also measured using a visual analogue scale. Results: There was no statistically significant difference in overall corneal staining between lens types (p = 0.16) or care regimens (p = 0.60). Central corneal staining was significantly greater for the polyquad-based care regimen when compared with the PHMB-based care regimen (p = 0.04). Lotrafilcon A lenses showed greater superior corneal staining (p = 0.0004) and papillary conjunctivitis (p = 0.02), and lower comfort on insertion (p = 0.03) when compared with galyfilcon A lenses regardless of the care regime used. There were no statistically significant differences in the other biomicrosopic signs and symptoms between the lens types and the care regimes. Conclusions: Both care regimes performed in a similar clinical manner and are valid for use with the two silicone hydrogel contact lenses used in this study.
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