Journal
NEUROIMAGE
Volume 35, Issue 1, Pages 166-174Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2006.10.040
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Funding
- NIDCD NIH HHS [R01 DC007694, R01 DC007694-01A1] Funding Source: Medline
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Reproducible Objective Quantification Scheme (ROQS) is a novel method for regional white matter measurements of diffusion tensor imaging (DTI) parameters that overcomes the limitations of previous approaches for analyzing large cohorts of subjects reliably. ROQS is a semi-automated technique that exploits the fiber orientation information from the diffusion tensor in conjunction with a binary masking and chain-linking algorithm to segment anatomically distinct white matter tracts for subsequent quantitative analysis of DTI parameters such as fractional anisotropy and apparent diffusion coefficient. When applied to 3-T whole-brain DTI of normal adult volunteers, ROQS is shown to segment the corpus callosum much faster than manual region of interest (ROI) delineation, and with better reproducibility and accuracy. (c) 2006 Elsevier Inc. All rights reserved.
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