Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 51, Issue 3, Pages 1109-1111Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01256-06
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- NIGMS NIH HHS [R01 GM065051, GM 065051] Funding Source: Medline
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We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.
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