Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 42, Issue 3, Pages 380-385Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2006.09.003
Keywords
thiazolo[2,3-b]dihydropyrimidinones; 4-methylthiophenyl; antibacterial; antifungal
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A series of new 2-(arylidene/5-arylfurfurylidene)-5-(4-methylthiophenyl)-6-carbethoxy-7 -methyl-5H-thiazolo [2,3 -b]pyrimidin-3 (1H)-ones 2 and 3 have been synthesized by a three component (MCR) reaction involving 4-(4-niethylthiophenyl)-5-carbethoxy-6-methyl-3,4-dihydropyrimidin-2(IH)-thione 1, monochloroacetic acid and arylaldehydes/arylfurfuraldehydes, respectively. The newly synthesized compounds were well characterized by elemental analysis, IR, H-1 NMR and mass spectral studies. The newly synthesized compounds were screened for their antibacterial and antifungal activities and have exhibited moderate to excellent growth inhibition of bacteria and fungi. The results of such studies have been discussed in this paper. (c) 2006 Elsevier Masson SAS. All rights reserved.
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