Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 24, Issue 3, Pages 868-874Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msm004
Keywords
mtDNA; complete sequences; asthenozoospermia; association
Funding
- Fundação para a Ciência e a Tecnologia [POCTI/SAU/97/2001, CONT_DOUT/111/UM/4050/11105/ 2/2008, PRAXIS XXI/BM/200/94] Funding Source: FCT
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The first complete mitochondrial DNA (mtDNA) sequences (similar to 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.
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