Journal
AUTOPHAGY
Volume 3, Issue 2, Pages 158-159Publisher
LANDES BIOSCIENCE
DOI: 10.4161/auto.3637
Keywords
Th1; Th2; homeostasis; effector T cell; apoptosis; autophagy; programmed cell death
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The population size of the T cells is tightly regulated. The T cell number drastically increases in response to their specific antigens. Upon antigen clearance, the T cell number decreases over time. Apoptosis, also called type I programmed cell death, plays an important role in eliminating T cells. The role of autophagic cell death, also called type II programmed cell death, is unclear in T cells. Our recent work demonstrated that autophagy is induced in both Th1 and Th2 cells. Both TCR signaling and IL-2 increase autophagy in T cells, and JNK MAP kinases are required for the induction of autophogy in T cells, whereas caspases and mTOR inhibit cutophagy in T cells. Autophagy is required for mediating growth factor withdrawal-dependent cell death in T cells. Here, we hypothesize that autophagic cell death plays an important role in T cell homeostasis.
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