Journal
GENOMICS
Volume 89, Issue 3, Pages 307-315Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2006.11.012
Keywords
human ORFeome; gateway system; clone resource; MGC collection; nucleotide substitution rate; OMIM; GO slim; visant; hORFDB; high-throughput cloning
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Complete sets of cloned protein-encoding open reading frames (ORFs), or ORFeomes, tire essential tools for large-scale proteomics and systems biology studies. Here we describe human ORFeome version 3.1 (hORFeome v3.1), Currently the largest publicly available resource of full-length human ORFs (available at www.openbiosystems.com). Generated by Gateway recombinational cloning, this collection contains 12,212 ORFs, representing 10,214 human genes, and corresponds to a 51% expansion of the original hORFeome v1.1. An online human CRFeome database, hORFDB, was built and serves as the central repository for all cloned human ORFs (http://horfdb.dfci.harvard.edu). This expansion of the original ORFeome resource greatly increases the potential experimental search space for large-scale proteomics studies, which will lead to the generation of more comprehensive datasets. (c) 2006 Elsevier Inc. All rights reserved.
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