Journal
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Volume 27, Issue 3, Pages 269-275Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0b013e31802e3e9b
Keywords
age-related macular degeneration; candidate gene; complement factor H; LOC387715; Y402H; 1q32; 6p21; 10q26
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Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 11q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed.
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