Journal
EXPERIMENTAL NEUROLOGY
Volume 204, Issue 1, Pages 260-263Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2006.11.002
Keywords
amyotrophic lateral sclerosis; animal model; neuroprotection; erythropoietin
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Erythropoietin (Epo) has been shown in the recent years to have neuroprotective activity in a variety of settings. In this study, we investigated its impact on the progression of paralysis in a mouse model simulating the human disorder amyotrophic lateral sclerosis (ALS). We found that Epo can delay the onset of motor deterioration in transgenic SOD G93A mice without prolonging their survival. Notably this effect was selective for the females only. These initial findings encourage further investigation of this biological avenue in the search for improved remedies for this fatal disease. (c) 2006 Elsevier Inc. All rights reserved.
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