Journal
BRAIN & DEVELOPMENT
Volume 29, Issue 2, Pages 83-91Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2006.07.002
Keywords
attention deficit hyperactivity disorder; resting-state functional MRI; amplitude; low-frequency fluctuation; spontaneous neuronal activity
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In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08 Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0 +/- 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD. (c) 2006 Elsevier B.V. All rights reserved.
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