Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 50, Issue 50, Pages 11860-11871Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201102027
Keywords
asymmetric catalysis; conformation analysis; fluorine; organocatalysis; stereoelectronic effects
Categories
Funding
- Alfred Werner Foundation
- Roche Research Foundation
- Novartis AG
- ETH Zurich
Ask authors/readers for more resources
Molecular design strategies that profit from the intrinsic stereoelectronic and electrostatic effects of fluorinated organic molecules have mainly been restricted to bio-organic chemistry. Indeed, many fluorine conformational effects remain academic curiosities with no immediate application. However, the renaissance of organocatalysis offers the possibility to exploit many of these well-described phenomena for molecular preorganization. In this minireview, we highlight examples of catalyst refinement by introduction of an aliphatic C?F bond which functions as a chemically inert steering group for conformational control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available