Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 38, Issue 2, Pages 100-101Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2006.10.005
Keywords
SiRNA; altritol nucleic acids; cyclohexenyl nucleic acids; P-glycoprotein expression
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Cyclohexenyl nucteic acids and altritol nucleic acids were evaluated as RNA modifications in an siRNA experiment targeting the P-glycoprotein expression. Both modified oligonucleotides are well accepted as RNA mimics leading to an increase in potency and duration of action of the gene-silencing effect. (c) 2006 Elsevier Inc. All rights reserved.
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