Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 5, Pages 1842-1845Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo062347b
Keywords
-
Categories
Ask authors/readers for more resources
A new efficient and flexible synthesis of fluorescently labeled sphingosine derivatives from commercially available Garner aldehyde (8) is described. For this, appropriate alkenylated borondipyrromethene (BODIPY) dyes were synthesized and used for the first time in a cross-metathesis reaction, the key step of the approach. The labeled sphingosines with appropriate chain length were accepted as substrates by sphingosine kinases (SPHKs), yielding the corresponding phosphorylated products. One of these derivatives (11d) was identified as the first reported selective substrate for SPHK-1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available