Toward the total synthesis of Scleritodermin A:: preparation of the C1-N15 fragment

The synthesis of the C-1-N-15 fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the alpha-keto amide linkage by the use of a highly activated alpha,beta-ketonitrile. (c) 2007 Elsevier Ltd. All rights reserved.