4.4 Article

Enzyme promiscuity:: first protein-catalyzed Morita-Baylis-Hillman reaction

Journal

TETRAHEDRON LETTERS
Volume 48, Issue 10, Pages 1679-1681

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.01.063

Keywords

Baylis-Hillman reactions; enzymes and enzyme reactions; proteins; asymmetric reactions; enantioselection

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The Morita-Baylis-Hillman reaction of cyclohexenone and p-nitro benzaldehyde is catalyzed by carrier proteins such as serum albumins or enzymes such as certain lipases, conversion of up to 35% and enantio selectivities of up to 19% being observed. (c) 2007 Elsevier Ltd. All rights reserved.

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