Journal
CHEMBIOCHEM
Volume 8, Issue 4, Pages 373-378Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200600473
Keywords
biosensors; fluorescent probes; peptides; protein tyrosine kinases; signal transduction
Funding
- NCI NIH HHS [R01 CA079954-07, R01 CA079954, CA79954] Funding Source: Medline
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Protein tyrosine kinases are key biochemical effectors of the signaling pathways that drive both normal and aberrant cell behavior. The ability to visualize the activity of tyrosine kinases in both a continuous and sensitive fashion will have a dramatic impact on the identification and characterization of inhibitors, the elucidation of the biochemical role of protein tyrosine kinases in various biological processes, and the imaging of kinase action in cells, tissues, and whole organisms. Several chemical strategies have recently been described that translate the formation of a phosphorylated tyrosine residue into a fluorescent readout. The challenges associated with the design of protein tyrosine kinase sensors, as well as the scope and limitations of the currently available sensors, ore described.
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