Journal
TETRAHEDRON LETTERS
Volume 48, Issue 10, Pages 1795-1799Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.01.030
Keywords
chemical protein synthesis; integral membrane proteins; diacylglycerol kinase; native chemical ligation; thioester
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Funding
- NICHD NIH HHS [T32 HD007009, T32 HD007009-34] Funding Source: Medline
- NIGMS NIH HHS [R01 GM075993, R01 GM075993-01] Funding Source: Medline
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Modification of a peptide-(alpha)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-(alpha)thioester building blocks for the total chemical synthesis of integral membrane proteins by native chemical ligation. (c) 2007 Elsevier Ltd. All rights reserved.
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