Journal
ADVANCED MATERIALS
Volume 19, Issue 5, Pages 711-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200602098
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Gold nanoparticles significantly inhibit proliferation in multiple myeloma cell lines (see figure) in a dose-dependent manner. Gold-treated multiple myeloma cells show cell-cycle arrest in the G1-phase (the phase when chromosomes prepare for replication) by up-regulation of cell-cycle cyclin-dependent kinase inhibitor proteins p21 and p27. Gold nanoparticles do not affect normal peripheral blood mononuclear cells.
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