Journal
FEBS LETTERS
Volume 581, Issue 5, Pages 879-884Publisher
WILEY
DOI: 10.1016/j.febslet.2007.01.050
Keywords
ARC; myogenic differentiation; H9c2 cells; caspase activation; apoptosis; heart
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Apoptosis repressor with caspase recruitment domain (ARC), an anti-apoptotic protein, is highly expressed in differentiated heart and skeletal muscle. Apoptosis and differentiation share numerous common pathways; therefore, we examined the impact of ARC on H9c2-myoblast differentiation. We demonstrate that ARC expression levels increase and stabilize upon differentiation. ARC-overexpression in pre-differentiated H9c2-cells suppresses differentiation; indicated by increased myotube formation, nuclear fusion and expression of the differentiation markers myogenin and troponin-T. ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition. In summary, we show a novel role for ARC in the regulation of muscle differentiation. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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