Journal
FEBS LETTERS
Volume 581, Issue 5, Pages 885-890Publisher
WILEY
DOI: 10.1016/j.febslet.2007.01.061
Keywords
20S proteasome; chymotrypsin-like activity; immunoproteasome; age-related macular degeneration
Funding
- NEI NIH HHS [T32 EY007133, EY014176, EY013623, T32 EY017133, R03 EY014176, R01 EY013623] Funding Source: Medline
- NIA NIH HHS [R01 AG025392, AG025392] Funding Source: Medline
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The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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