Cytochromes P460 and c′-beta;: A new family of high-spin cytochromes c

Cytochromes-P460 of Nitrosomonas europaea and Methylococcus capsulatus (Bath), and the cytochrome c' of M. capsulatus, believed to be involved in binding or transformation of N-oxides, are shown to represent an evolutionarily related new family of monoheme, similar to 17 kDa, cytochromes e found in the genomes of diverse Protcobacteria. All members of this family have a predicted secondary structure predominantly of beta-sheets in contrast to the predominantly alpha-helical cytochromes c' found in photoheterotrophic and denitrifying Proteobacteria. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.