Journal
NEUROSCIENCE LETTERS
Volume 414, Issue 2, Pages 141-144Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.12.008
Keywords
tau; ApoE; phenotype; association study; hallucinations; dementia; post-mortem
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Funding
- NIA NIH HHS [P01 AG17216] Funding Source: Medline
- NIEHS NIH HHS [R01 ES013941] Funding Source: Medline
- NIMH NIH HHS [R03 MH074059, R03 MH074059-02] Funding Source: Medline
- NINDS NIH HHS [P50 NS40256] Funding Source: Medline
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Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and HIM genotype. We also report an association between PDD and the presence of the ApoE epsilon 4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies. (c) 2006 Published by Elsevier Ireland Ltd.
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