Journal
FEBS LETTERS
Volume 581, Issue 5, Pages 967-974Publisher
WILEY
DOI: 10.1016/j.febslet.2007.01.084
Keywords
3BP2; CIN85; HIP-55; Src homology 3 domain; proline-rich domain
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The adapter 3BP2 is involved in leukocyte signaling downstream Src/Syk-kinases coupled immunoreceptors. Here, we show that 3BP2 directly interacts with the endocytic scaffold protein CIN85 and the actin-binding protein HIP-55. 3BP2 colocalized with CIN85 and HIP-55 in T cell rafts and at the T cell/APC synapse, an active zone of receptors and proteins recycling. A binding region of CIN85 SH3 domains on 3BP2 was mapped to a PVPTPR motif in the first proline-rich region of 3BP2, whereas the C-terminal SH3 domain of HIP-55 bound a more distal proline-rich domain of 3BP2. Together, our data suggest an unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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