Journal
FEBS LETTERS
Volume 581, Issue 5, Pages 962-966Publisher
WILEY
DOI: 10.1016/j.febslet.2007.01.079
Keywords
angiogenesis; allosteric effector; chorioallantoic membrane; haemoglobin; inositol hexakisphosphate; inositol trispyrophosphate; partial oxygen pressure; tumor; vascular quantification
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We investigate here the anti-angiogenic properties of the synthetic compound myo-inositol trispyrophosphate (ITPP). By increasing oxy-haemoglobin dissociation, ITPP has the potential to counteract the effects of hypoxia, a critical regulator of angiogenesis and cancer progression. ITPP inhibited angiogenesis of the chorioallantoic membrane (CAM), as analyzed with an original program dedicated to automated quantification of angiogenesis in this model. ITPP also markedly reduced tumor progression and angiogenesis in an experimental model of U87 glioma cell nodules grafted onto the CAM. These results point out the potential of ITPP for the development of a new class of anti-angiogenic and anti-cancer compounds. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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