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Obesity-related immune responses and their impact on surgical outcomes

Journal

INTERNATIONAL JOURNAL OF OBESITY
Volume 39, Issue 6, Pages 877-883

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ijo.2015.21

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Funding

  1. IFB Integrated Research and Treatment Center Adiposity Diseases
  2. NIH [RO-1 AG039449]
  3. Instituto Carlos Slim de la Salud

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The obesity epidemic represents a critical disease burden with broad clinical consequences. At the same time, obesity has been linked to inferior surgical outcomes and considered a contraindication for some elective surgical procedures. A growing body of mechanistic evidence has accumulated linking obesity to changes of metabolism and immune responses. This concept provides an integrated inflammatory network based on the perception of obesity as a state of chronic low-grade inflammation. With a more detailed understanding of this dynamic network and mechanistic insights, novel treatment and management strategies may be developed with the goal to optimize surgical outcomes in obese patients.

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