Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 5, Pages 897-900Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm061207r
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Optimization of a pyrrolidine-based template using structure-based design and physicochemical considerations has provided a development candidate 20b (3082) with submicromolar potency in the HCV replicon and good pharmacokinetic properties.
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