Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 354, Issue 2, Pages 434-439Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2006.12.231
Keywords
angiogenesis; inhibitor; endogenous; endothelial cell; tetrastatin; pentastatin; hexastatin
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Funding
- NCI NIH HHS [P50 CA103175, R01 CA138264] Funding Source: Medline
- NHLBI NIH HHS [R01 HL079653] Funding Source: Medline
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Angiogenesis, or neovascularization, is tightly controlled by positive and negative regulators, many of which reside in the extracellular matrix. We have now identified eight novel 19- to 20-residue peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils of type IV collagen, which we have designated tetrastatins, pentastatins, and hexastatins, respectively. We have shown that these endogenous peptides suppress the proliferation and migration of HUVECs in vitro. By performing clustering analyses of the sequences using sequence similarity criteria and of the experimental results using a hierarchical algorithm, we report that the clusters identified by the experimental results coincide with the sequence-based clusters, indicating a tight relationship between peptide sequence and anti-angiogenic potency. These peptides may have potential as anti-angiogenic therapeutic agents. (c) 2007 Elsevier Inc. All rights reserved.
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