Journal
TETRAHEDRON
Volume 63, Issue 11, Pages 2404-2408Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.01.015
Keywords
direct Mannich-type reaction; beta-amino ketones; silica sulfuric acid; synthesis
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At room temperature, the direct Mannich-type reaction of a variety of in situ generated aldimines using aldehydes and anilines with ketones in a three-component reaction was efficiently catalyzed by silica sulfuric acid (SSA) in EtOH. This rapid reaction afforded the corresponding beta-amino ketones in good yields with excellent stereoselectivities and catalyst was recyclable. (c) 2007 Elsevier Ltd. All rights reserved.
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