4.4 Article

A simple TiCl4 promoted arylation of orthoformate and benzyl ethers by N,N-dialkylarylamines

Journal

TETRAHEDRON LETTERS
Volume 48, Issue 11, Pages 1955-1958

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.01.079

Keywords

N,N-dialkylarylamines; trimethyl orthoformate; formylation; titanium tetrachloride

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N,N-Dialkylarylamines react with trimethyl orthotormate and TiCl4 under ambient conditions to give the corresponding formyl derivatives in 75-89% yields, whereas the corresponding arylated products are obtained from benzyl ethers and acetals in 42-78% yields. (c) 2007 Published by Elsevier Ltd.

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