4.0 Article

Enantioselective desymmetrization of meso-N-sulfonylaziridines with thiols

Journal

TETRAHEDRON-ASYMMETRY
Volume 18, Issue 4, Pages 443-446

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2007.02.017

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Desymmetrization of nieso-N-sulfonylaziridines with thiols was realized using cinchonine-derived chiral quaternary ammonium salts as the catalyst. The corresponding chiral thio amines were provided in high yields (80-99%) and in good enantio selectivities (40-73% ee). (c) 2007 Elsevier Ltd. All rights reserved.

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