Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 11, Pages 4332-4336Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0611471104
Keywords
cytoskeleton; molecular motor; motility; processivity
Categories
Funding
- NHLBI NIH HHS [R01 HL038113, HL 38113] Funding Source: Medline
- NIAMS NIH HHS [AR 47906, P01 AR047906] Funding Source: Medline
- NIGMS NIH HHS [GM 026338, K25 GM072123, R01 GM026338, GM 072123] Funding Source: Medline
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Certain types of intracellular organelle transport to the cell periphery are thought to involve long-range movement on microtubules by kinesin with subsequent handoff to vertebrate myosin Va (myoVa) for local delivery on actin tracks. This process may involve direct interactions between these two processive motors. Here we demonstrate using single molecule in vitro techniques that myoVa is flexible enough to effectively maneuver its way through actin filament intersections and Arp2/3 branches. In addition, myoVa surprisingly undergoes a one-dimensional diffusive search along microtubules, which may allow it to scan efficiently for kinesin and/or its cargo. These features of myoVa may help ensure efficient cargo delivery from the cell center to the periphery.
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