Journal
JOURNAL OF IMMUNOLOGY
Volume 178, Issue 6, Pages 3358-3362Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.178.6.3358
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Funding
- NIAID NIH HHS [R01 AI046784-09, R01 AI046784, R01 AI046784-08, R01 AI046784-10, R01 AI 046784] Funding Source: Medline
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Dual expression of chemokine receptor CCR4 and E-selectin ligand is characteristic of skin-tropic CD4 T cells from blood, lymphoid organs, and the skin itself. A strong and specific correlation exists among CCR4, its ligand CCL17/TARC, and the cutaneous lymphocyte-homing process. Nevertheless, whether CCR4 function is required for skin-specific trafficking remains an open question, which we address in this study. We developed an Ag-specific, TCR-transgenic, murine CD4 T cell adoptive transfer model that induces a mixed Th1 and Th17 cutaneous response. Within the hosts, both CCR4(+/+) and CCR4(-/-) donor CD4 T cells contribute equally well to the circulating E-selectin ligand(+) pool in response to Ag. However, only CCR4(+/+) donor cells accumulate effeciently within the skin. CCR4(-/-) cells home normally to the peritoneum, showing that they do not have a general defect in lymphocyte trafficking. We conclude that under physiological conditions, CCR4 is a nonredundant, necessary component of skin-specific lymphocyte trafficking.
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