Journal
JOURNAL OF APPLIED PHYSICS
Volume 101, Issue 6, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.2511688
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Funding
- NHGRI NIH HHS [R01 HG002644-01A1, R01 HG002644] Funding Source: Medline
- NIBIB NIH HHS [K99 EB007151, K99 EB007151-01] Funding Source: Medline
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A systematic experimental study and theoretical modeling of the device physics of polydimethylsiloxane pushdown microfluidic valves are presented. The phase space is charted by 1587 dimension combinations and encompasses 45-295 mu m lateral dimensions, 16-39 mu m membrane thickness, and 1-28 psi closing pressure. Three linear models are developed and tested against the empirical data, and then combined into a fourth-power-polynomial superposition. The experimentally validated final model offers a useful quantitative prediction for a valve's properties as a function of its dimensions. Typical valves (80-150 mu m width) are shown to behave like thin springs. (c) 2007 American Institute of Physics.
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