Journal
CLINICAL CANCER RESEARCH
Volume 13, Issue 6, Pages 1656-1662Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-06-2659
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Funding
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [CA095458] Funding Source: Medline
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Metastasis to the brain is prevalent in solid tumors and lymphomas, and is associated with shortened survival. The brain is regarded as a sanctuary site for metastatic tumor cells where they exist partially protected from drugs by the blood-tumor barrier. Model systems for brain metastasis have been developed and are now yielding mechanistic insights into the roles of angiogenesis, energy metabolism, the Her-2 and Stat3 signaling pathways, and dormancy. Specific, new approaches to combat brain metastatic disease are needed.
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