Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 6, Pages 1705-1707Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.12.070
Keywords
Bacillus subtilis; ComX; posttranslational modification; quorum sensing; structure-activity relationship
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Funding
- NIGMS NIH HHS [GM 57720, R01 GM057720-38, R01 GM057720] Funding Source: Medline
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The ComX pheromone is a posttranslationally modified oligopeptide that stimulates natural genetic competence in Bacillus subtilis. Various ComX(RO-E-2) analogs were synthesized and their biological activities were studied to investigate structure-activity relationships. These results showed that the minimal active unit was the tripeptide, [3-5]ComX(RO-E-2), and all residues except the modified tryptophan residue were replaceable by alanine without total loss of activity. (c) 2007 Elsevier Ltd. All rights reserved.
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