Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 6, Pages 1622-1625Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.12.082
Keywords
vitamin K; metabolite; apoptosis; analogue; menaquinone-4
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Novel omega-oxygenated vitamin K-2 analogues, which are candidates for metabolites of vitamin K-2 homologues, were efficiently synthesized and their apoptosis-inducing activity was evaluated. We revealed that some of those analogues were biologically active and the side-chain part played an important role in apoptosis-inducing activity. Our results can provide useful information to develop the structure-activity relationship of vitamin K-2 analogues for new drugs based on vitamin K. (c) 2007 Elsevier Ltd. All rights reserved.
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