Journal
PHYSICAL REVIEW LETTERS
Volume 98, Issue 11, Pages -Publisher
AMERICAN PHYSICAL SOC
DOI: 10.1103/PhysRevLett.98.116001
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Funding
- NCRR NIH HHS [R21 RR023149, R21-RR023149, R21 RR023149-01] Funding Source: Medline
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We observed single molecules of fluorescently labeled double-stranded (ds) lambda DNA held in an anti-Brownian electrokinetic trap. From the measured density fluctuations we extract the density-density response function of the molecule over times > 4.5 ms and distances > 250 nm, i.e., how a perturbation in density in one part of the molecule propagates through the rest of the molecule. We find a nonmonotonic radial dependence of the relaxation time. In contrast with earlier measurements on freely diffusing dsDNA, we observe clear signs of internal hydrodynamic interactions.
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