Journal
SYNLETT
Volume -, Issue 5, Pages 704-708Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2007-970783
Keywords
ethynyl ketones; pyrazoles; heterocycles; microwave synthesis; concurrent heating and cooling
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Funding
- Engineering and Physical Sciences Research Council [GR/S41463/01] Funding Source: researchfish
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Reaction of alpha,beta-ethynyl ketones and hydrazine derivatives gives 1,3- and 1, 5 -disubstituted pyrazoles in good yield. Microwave irradiation in concentrated hydrochloric acid-methanol (1.5% v/v), with concurrent cooling at sub-ambient temperatures or at 120 degrees C, for 30 or 2 minutes, respectively, facilitates rapid heterocyclization and preferentially gives the 1,3 -disubstituted regioisomer.
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