Journal
NEUROSCIENCE
Volume 145, Issue 2, Pages 464-469Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2006.12.015
Keywords
pyramidal neurons; excitatory synapses; serial section reconstructions
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Funding
- NEI NIH HHS [EY11787] Funding Source: Medline
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Along-held assumption states that each dendritic spine in the cerebral cortex forms a synapse, although this issue has not been systematically investigated. We performed complete ultrastructural reconstructions of a large (n=144) population of identified spines in adult mouse neocortex finding that only 3.6% of the spines clearly lacked synapses. Nonsynaptic spines were small and had no clear head, resembling dendritic filopodia, and could represent a source of new synaptic connections in the adult cerebral cortex. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.
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