Journal
CANCER LETTERS
Volume 247, Issue 2, Pages 197-203Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2006.04.004
Keywords
Cdx; allelic imbalance; gene amplification
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The expression of the CDX2 gene, a crucial regulator of gut homeostasis, is altered in human colorectal cancers in parallel with de-differentiation. Here, we have investigated the chromosomal status of CDX2 in human sporadic colorectal cancers with the phenotype of chromosomal instability. Allelic imbalance determination showed frequent rearrangements at the CDX2 locus. The rearrangements correlated with CDX2 gene amplification, as assessed by quantitative PCR analysis. However, they were not predictive of the Cdx2 protein pattern. These data suggest that mechanisms other than structural alterations at the CDX2 locus account for the change of expression in colorectal cancers. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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