Journal
TETRAHEDRON LETTERS
Volume 48, Issue 12, Pages 2097-2099Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.01.130
Keywords
one-pot reactions; 1,2,3-triazoles; cycloadditions
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1,4-Disubstituted 1,2,3-triazoles were obtained by a high-yielding copper(1) catalyzed 1,3-dipolar cycloaddition reaction between in situ generated azides and terminal acetylenes. This one-pot, two-step procedure tolerates most functional groups and circumvents the problems associated with the isolation of potentially toxic and explosive organic azides. (c) 2007 Elsevier Ltd. All rights reserved.
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