Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells

Expression of CUB domain containing protein I (CDCPI) is upregulated in carcinoma cells. We quantitated CDCPI gene expression in matched normal colon and tumour tissue and compared the level of expression to other genes upregulated in colorectal tumourigenesis. Furthermore, we show that the CDCPI gene generates two transcripts which are co-expressed in normal and matched tumour tissue as well as in the majority of cell lines analysed. However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.