Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 161, Issue 1, Pages 118-125Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2006.10.025
Keywords
brain stimulation; rat; motor cortex; motor evoked potential; cortical mapping
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Stimulation mapping of motor cortex is an important tool for assessing motor cortex physiology. Existing techniques include intracortical microstimulation (ICMS) which has high spatial resolution but damages cortical integrity by needle penetrations, and transcranial stimulation which is non-invasive but lacks focality and spatial resolution. A minimally invasive epidural microstimulation (EMS) technique using chronically implanted polyimide-based thin-film microelectrode arrays (72 contacts) was tested in rat motor cortex and compared to ICMS within individual animals. Results demonstrate reliable mapping with high reproducibility and validity with respect to ICMS. No histological evidence of cortical damage and the absence of motor deficits as determined by performance of a motor skill reaching task, demonstrate the safety of the method. EMS is specifically suitable for experiments integrating electrophysiology with behavioral and molecular biology techniques. (c) 2006 Elsevier B.V. All rights reserved.
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