Journal
NEUROSCIENCE LETTERS
Volume 415, Issue 3, Pages 237-241Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2007.01.074
Keywords
estrogen; cerebral-ischemia; neuroprotection
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Funding
- NIA NIH HHS [P01 AG022550-04, AG 10485, P01 AG010485, P01 AG010485-14, AG 22550, P01 AG022550] Funding Source: Medline
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The present study was undertaken to determine if the neuroprotective effect of 17 beta-estradiol (E-2) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E, at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E, extended the therapeutic window to 6h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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