Journal
NEUROSCIENCE
Volume 145, Issue 3, Pages 1130-1137Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2006.12.032
Keywords
ocular chemesthesis; homologous n-aldehydes; homologous carboxylic acids; eye irritation detection; molecular cutoff; ocular trigeminal chemosensitivity
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Funding
- NIDCD NIH HHS [R01 DC005003-04, R01 DC 005003, R01 DC005003-03, R01 DC005003] Funding Source: Medline
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Using neat vapors of selected homologous aldehydes (decanal, undecanal, dodecanal) and carboxylic acids (pentanoic, hexanoic, heptanoic, octanoic, nonanoic), we explored the point where a certain homolog (and all larger ones) becomes undetectable by eye irritation (i.e. by ocular chemesthesis). This phenomenon has been observed in other homologous series that also reach a break-point, or cutoff, in chemesthetic detection. Participants (11 <= n <= 32) were tested using a three-alternative, forced-choice procedure. Flow rate to the eye equaled 4 or 8 l/min and time of exposure was 6 s. The outcome showed that dodecanal and heptanoic acid were the shortest undetectable homologs. When the vapor concentration of the stimuli was increased by heating the liquid source to 37 degrees C, homologs located before the cutoff point (e.g. hexanoic acid) became readily detected by all subjects, whereas homologs located at the cutoff remained largely undetected. In addition, a comparison of calculated values of eye irritation thresholds for aldehydes and acids (from a successful model of ocular chemesthetic potency) with values of saturated vapor concentration at 23 and 37 degrees C indicated that the vapor concentration of dodecanal and heptanoic acid should have been enough to produce detection. The outcome suggests that the cutoff observed does not result from a low vapor concentration but from limitations in the structure or dimension(s) of the molecules that render them unsuitable to interact effectively with human chemesthetic receptors. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.
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