4.7 Article

Synthesis of optically active bifunctional building blocks through enantioselective copper-catalyzed allylic alkylation using Grignard reagents

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 7, Pages 2558-2563

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo0625655

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Enantioselective copper-catalyzed allylic alkylations were performed on allylic bromides with a protected hydroxyl or amine functional group using several Grignard reagents and Taniaphos L1 as a ligand. The terminal olefin moiety in the products was transformed into various functional groups without racemization, providing facile access to a variety of versatile bifunctional chiral building blocks.

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